Cambridge Healthtech Institute’s Fifth Annual
Protein Aggregation and Emerging Analytical Tools
PepTalk: The Protein Science Week
January 16-17, 2014
This annual conference covers the latest trends, challenges and solutions in protein aggregation. It features in-depth case studies and interactive discussions on mechanisms of aggregation, detection and quantitation of aggregates, characterization tools, visible and sub-visible protein aggregation detection and analysis techniques. It will also present case studies on prevention of particle formation, impact of aggregation on production, aggregates as a factor for immunogenicity, and approaches for improvement of biophysical properties of protein solutions as related to their drugability.
Join with colleagues from around the world in this discussion of the key challenges and solutions in protein aggregation, and see how experts like you are overcoming analytic, formulation, manufacturing, and regulatory challenges to create a stable formulation.
We invite presentation proposals on the following preliminary topics:
- Qualitative and quantitative aspects of aggregation in protein therapeutics
- Regulatory considerations related to aggregates and validation using analytical tools
- Computational biophysics and structural analysis to understand and predict protein aggregation
- Development, qualification, and implementation of biophysical methods to study aggregation
- Analytical tools for studying protein structure and dynamics as related to aggregation: Circular dichroism (CD), FTIR, Hydrogen exchange mass spectrometry (HDX), differential scanning calorimetry (DSC), crystallography, NMR, Ultra centrifugation, static and dynamic light scattering, mass spectrometry (MS), size exclusion chromatography (SEC), turbidity and calorimetry
- Protein unfolding and loss of colloidal stability as major mechanisms of aggregation
- Conducting proper analytics up front in discovery to avoid dealing with aggregation later
- Higher order aggregates and particles: Prevention and detection
- Visible and sub-visible protein aggregation detection and analysis techniques
- Tools and techniques to characterize heterogeneity in biologics (deamidation, isomerization, oxidation, disulfide scrambling, unfolding, etc., all of which lead to aggregation and other heterogeneities)
- The impact of protein aggregation on production: Considerations from the bench to scale-up
- Purification methods to remove protein aggregates and their scalability
- Antibody-drug conjugates (ADCs): How the drug and the conjugation process affect propensity for aggregation, and how ADCs are formulated
- Immunogenicity of protein therapeutics: Aggregates as an inducing factor?
- Detection of biological activity of protein aggregates
- Problems in membrane protein aggregation; measurements in the presence of surfactants & detergents
- Ligand interactions that promote protein stability and prevent aggregation
- Design of stabilizers against protein aggregation
- Controlling adverse protein aggregation induction during patient handling and use
- Aggregation issues in small alternative protein scaffolds
- Aggregation of bispecific antibodies
Please click here to submit a speaking proposal for review.
Deadline for submission: June 7, 2013
All proposals are subject to review by the Scientific Advisory Committee to ensure the overall quality of the conference program. Please note that due to limited speaking slots, preference will be given to abstracts from those within pharmaceutical and biopharmaceutical companies, regulators and those from academic centers. Additionally, as per CHI policy, a select number of vendors/consultants who provide products and services to these biopharmaceutical companies are offered opportunities for podium presentation slots based on a variety of Corporate Sponsorships.
For questions about the meeting, contact: Nandini Kashyap
Conference Director
Cambridge Healthtech Institute
Phone: 781-972-5406
Email: nkashyap@healthtech.com
For partnering & sponsorship information, please contact:
Companies A-K
Jason Gerardi
Manager, Business Development
Cambridge Healthtech Institute
Phone: 781-972-5452
Fax: 781-972-5470
Email: jgerardi@healthtech.com
Companies L-Z
Carol Dinerstein
Director, Business Development
Cambridge Healthtech Institute
Phone: 781-972-5471
Fax: 781-972-5470
Email: dinerstein@healthtech.com