January 13 - 17, 2014
Renaissance Hotel and Palm Springs Convention Center Palm Springs, California

A Community Dedicated to the
Evolving Field and Future of Biotherapeutics
2014 Archived Content



Sunday, January 12 | 5:00-8:00 pm


While GPCRs (G protein-coupled receptors) are important therapeutic targets, it has been challenging to discover therapeutically relevant antibodies against them.  This course will examine different steps along the anti-GPCR antibody discovery pathway and highlight various approaches to accomplishing each step.  The topics to be covered include: antibody discovery, including methods to generate antibodies and antigen preparation; assays to evaluate antibody binding using cells expressing the GPCR of interest; and in vitro assays to measure functional activity of the antibody, including antagonism, agonism, or synergism/allosteric modulation using  chemotaxis, calcium, cAMP or other cell-based assays; and 4) review of promising GPCR targets and therapeutic antibodies currently in  clinical development.


The material to be presented in this short course includes:

  • Brief review of GPCRs, including structure, mechanism and role in diseases such as cancer, inflammation and metabolic disease
  • Methods for antibody discovery
  • in vitro assays for antibody characterization
  • Review of relevant kinetics, including agonism, antagonism and allosteric modulation
  • Review of GPCR-targeting antibodies in the clinic
  • Open discussion



Barbara Swanson, Ph.D., Director, Research, Sorrento Therapeutics, Inc.

Speaker Biography

BarbaraSwansonBarbara Swanson, Ph.D., Director, Research, Sorrento Therapeutics, Inc.

Barbara Swanson, Ph.D., is a Director of Research at Sorrento Therapeutics, where she leads the programs to discover therapeutic antibodies against GPCRs and to optimize therapeutic antibodies. In previous industrial positions she discovered antibodies against membrane-bound proteins including GPCRs. Using protein engineering techniques she has improved industrial enzymes, peptides and therapeutic antibodies, with several of her optimized antibodies in clinical trials. Dr. Swanson received her B.S. in Chemistry from MIT and her Ph.D. in Pharmaceutical Chemistry from the University of California at San Francisco.

«Back to Short Courses

Japan-Flag Korea-Flag China-Simplified-Flag China-Traditional-Flag 

PTK Event APP 
New this year!
The PepTalk App will allow attendees to browse the agenda, create custom schedules, navigate the exhibit hall and explore poster presentations.

2014 Brochure Cover 

Right Arrow Download the Brochure 

Right Arrow Event at-a Glance 

      Premier Sponsors: 

EMD Millipore 

 Novozymes (white) 

PerkinElmer NEW 2009 

 Protein Simple  


Right Arrow View All Sponsors 

Right Arrow View Media Partners 

Add to Outlook Add to Outlook 

Training Seminars 

Mon-Tues, January 13-14 

Biologics Formulation and Delivery  


Buzz Sessions
BuzZ Sessions are facilitated, small-group discussions. Interactive participation leads to problem-solving solutions and future collaborations around focused topics.
Click here for BuzZ topics