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2014 Archived Content

SHORT COURSE 3: VACCINE FORMULATION AND CHARACTERIZATION, STATUS QUO AND NEW OPPORTUNITIES

 

Sunday, January 12 | 5:00-8:00 pm



After water sanitization, vaccines may be the most successful method of preventing deadly or devastating infectious diseases. To overcome the hurdles that reduce vaccine efficacy, novel techniques to identify and improve vaccines are necessary. These new approaches help increase potency but also challenges related to formulation characterization and the stability of each component. The course will describe the current status of vaccine formulation characterization with a focus on alum-based formulations and describe steps that can improve it.

The topics to be covered:

  • Vaccine formulations and how they differ from other biologics
  • Why adjuvants are often used in vaccine formulations
  • Which are the most common adjuvants used in vaccines?
  • How do the characteristics of different vaccine formulations impact drug product characterization?
  • Strategies to overcome analytical challenges associated with vaccine characterization

 

Instructor:

Michele Pallaoro, Ph.D., Unit Head, Formulation Analytics, Novartis Vaccines & Diagnostics


Speaker Biography

MichelePallaoroMichele Pallaoro, Ph.D., Unit Head, Formulation Analytics, Novartis Vaccines & Diagnostics

Michele Pallaoro first graduated in Biology at the University of Rome La Sapienza, then obtained a Ph.D. in Biochemistry. After two years at the University of California where he grew his interest for Biochemistry and protein engineering, he came back to Italy to take a junior research position at IRBM (Merck & Co). Here he made relevant contributions in several projects ranging from anti-HCV to anti-tumoral programs. After ten years, he moved to Novartis Vaccines and Diagnostics, where he is currently leading the Formulation Analytical Unit. Michele Pallaoro is author or co-author of several research papers and reviews in peer-reviewed journals and holds several patents.



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