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With biologic drugs becoming more prominent in the marketplace, antibody researchers are now turning their attention to new indications, improved targeting, new formats and products that are truly differentiated relative to competitors. The new Antibody Optimization and Development pipeline offers a valuable, weeklong exploration of state-of-the-art approaches for improving the fundamental quality and efficacy of therapeutic antibodies - and for maximizing their potential as marketed drug products.
The world of protein-based therapeutics merits exploration, from novel constructs to enhanced in vivo effects, including antibodies as well as recombinant protein therapeutics. The varied designs, development and clinical data of fusion proteins, plus antibody-drug conjugates including linker technologies, specificity and enhancing properties, dovetail with discussion of bispecifics and how to create effective, multispecific antibodies that conquer cancer and other maladies. The Protein and Antibody Therapeutics pipeline showcases the array of therapeutics under development and their data of efficacy.
As the industry works to optimize the biotherapeutic development process, the formulation function must now play an earlier role in the pipeline, assisting with the selection and optimization of molecules with improved developability. The popular Formulation and Stability pipeline presents case studies of the latest tools, technologies and approaches related to the progression of biologics from research into high-quality product formats.
The complexity and sensitivity of biologic drugs present a set of unique challenges related to their packaging, storage and delivery, requiring drug developers to consider the impacts of materials, temperature, mechanical stresses and time. The Delivery and Packaging pipeline is a focused examination of how to consider and best control these factors in the development of safe, patient-friendly biotherapeutics.
The demand for high-quality biotherapeutics has never been greater. Higher-throughput protein expression, production and purificatin as well as more flexible expression systems and techniques are necessary to meet the demands for both biotherapeutic research and manufacturing pipelines. The Expression and Production pipeline explores the newest data, innovations and strategies to make the expression of therapeutic proteins more efficient, effective and trouble-free.
How do we overcome proteins’ challenging nature and achieve purified proteins? Insights can arise by exploring how to optimize the processes of protein purification and how to develop methods that translate into scale-up, including test usage, modeling and automation. Throughout the week, the Purification and Aggregation pipeline highlights analytical tools and methods for detecting protein aggregation in the quest for solubility and manufacturability.
Single-use technologies have been widely acknowledged as the enabler for continuous processing and flexible, modular facilities that will help increase throughput, reduce turnover time, facilitate multiproduct manufacturing and allow replication in multiple locations. At the same time, extractables and leachables and toxicological-biochemical challenges must be addressed as part of the validation process for these new systems and facilities to ensure the safe manufacture of efficacious biopharmaceuticals. The Manufacturing and Facilities pipeline reviews the technologies, processes and hurdles that need to be overcome to launch the biopharmaceutical industry’s facilities of the future.
Promote your company’s latest technology and/or solution at PepTalk. A limited number of agenda presentations (as part of a sponsorship package), exhibit space, branding, and promotional opportunities are available.
Year-over-year Peptalk: The Protein Science Week continues to draws leaders of biotherapeutics from industry and academia pioneering the evolution of biologics. The international delegation is comprised of over 1,200 participants from 20+ countries.
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BuzZ Sessions are facilitated, small-group discussions. Interactive participation leads to problem-solving solutions and future collaborations around focused topics.