January 18-22, 2016 | Town and Country Resort Hotel | SAN DIEGO, CA 
January 18-22, 2016 | Town and Country Resort Hotel | SAN DIEGO, CA 

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Cambridge Healthtech Institute’s 7th Annual
Protein Aggregation and Emerging Analytical Tools
Mechanism, Prediction, Screening, Immunogenicity and Formulation Challenges
January 21-22, 2016

The popular Protein Aggregation and Emerging Analytical Tools conference covers latest trends, challenges and solutions in understanding, characterization and mitigation of protein aggregation. It features in-depth case studies, new and unpublished data and interactive discussions on mechanisms of aggregation, new tools for detection and quantitation of aggregates, and how the data is used in regulatory filings. It also discusses mechanistic understanding of protein aggregation and present case studies on prevention of particle formation by engineering and formulation approaches, impact of aggregation on production, aggregates as a factor for immunogenicity, and approaches for improvement of biophysical properties of protein solutions. We are looking for cutting-edge research findings and unpublished data to be featured at this forum.

We invite you to submit a proposal, present a poster and join colleagues from around the world in this discussion of the key challenges and solutions in protein aggregation in biotherapeutics.

We invite presentation proposals on the following preliminary topics: 

  • Mechanistic understanding and prediction of protein aggregation, especially for new biotherapeutics such as antibody-drug conjugates (ADCs), bispecifics, multispecifics, etc.
  • Antibody-drug conjugates (ADCs): How the drug and the conjugation process affect propensity for aggregation, and how ADCs are formulated to prevent or overcome aggregation
  • Protein aggregation and degradation routes in high concentrations protein formulations
  • Design of aggregation-resistant biotherapeutics: Ligand interactions that promote protein stability and prevent aggregation
  • Formulation, process and manufacturing strategies to prevent and/or overcome aggregation challenges in early and late stage development
  • Aggregation and viscosity challenges in fill finish processes: Protein aggregates clogging the filter, filter validation studies, ultrafiltration / diafiltration (UF / DF)
  • Rapid and high-throughput tools for prediction and measurement of aggregation, viscosity and solubility
  • New analytical tools: Development, qualification and implementation analytical tools for studying protein structure and dynamics as related to aggregation
  • Higher-order structure characterization
  • Detection and characterization of biological activity of protein aggregates in vivo 
  • Immunogenicity of protein therapeutics: Aggregates as an inducing factor? Controlling adverse protein aggregation induction during patient handling and use
  • Interaction of extractable & leachables with protein and its impact on aggregation, stability, potency and immunogenicity of drug substance and drug product

Please click here to submit a speaking proposal for review.  

Deadline for submission: June 17, 2015 

All proposals are subject to review by the Scientific Advisory Committee to ensure the overall quality of the conference program. Please note that due to limited speaking slots, preference will be given to abstracts from those within pharmaceutical and biopharmaceutical companies, regulators and those from academic centers. Additionally, as per CHI policy, a select number of vendors/consultants who provide products and services to these biopharmaceutical companies are offered opportunities for podium presentation slots based on a variety of Corporate Sponsorships. 

For questions about the meeting, please contact:

Nandini Kashyap
Conference Director
Cambridge Healthtech Institute
Phone: 781-972-5406
Email: nkashyap@healthtech.com 

For partnering & sponsorship information, please contact: 

Companies A-K
Jason Gerardi
Manager, Business Development
Cambridge Healthtech Institute
Phone: 781-972-5452
Fax: 781-972-5470
Email: jgerardi@healthtech.com 

Companies L-Z
Carol Dinerstein
Director, Business Development
Cambridge Healthtech Institute
Phone: 781-972-5471
Fax: 781-972-5470
Email: dinerstein@healthtech.com