Nathan Lewis, PhD, Associate Professor, Pediatrics and Bioengineering, University of California, San Diego (UCSD)
Each protein secreted by a cell depends on up to hundreds of different host cell proteins for its synthesis, folding, post-translational modification, and transport. However, this secretory pathway machinery required can differ considerably. Using computational modeling and omics data integration, we have developed a pipeline to identify the host machinery that can be augmented to improve secretion of diverse recombinant biotherapeutics of interest.