PepTalk 2017
PepTalk 2017

Pipeline Four Header

Cambridge Healthtech Institute’s Ninth Annual
Engineering Genes and Hosts
Strategies in Systems and Synthetic Biology
January 9-10, 2017 | Hilton San Diego Bayfront | San Diego, CA


Engineering therapeutic protein expression platforms is not for the faint of heart. Many variables must be considered during the engineering process, including verification and sequence analysis of the gene or protein of interest, codon optimization, vector construction and clone/host selection. When challenges arise, protein expression engineers must design new cloning schemes by altering the DNA or amino acid sequence, moving a gene from one vector to another, transfecting the vector to an alternative host, re-selecting the clone, re-characterizing the expressed protein or any of the above – a laborious, time-consuming and expensive process.

Cambridge Healthtech Institute’s Ninth Annual Engineering Genes and Hosts conference continues the tradition of applying effective engineering strategies for protein expression and production research leading to functional biotherapeutic products. Learn from seasoned, savvy researchers as they share their real-world experiences, applications and results.

Preliminary Agenda


KEYNOTE PRESENTATION: Systems Engineering as a Strategy for Developing New Therapeutics against Infectious Diseases and Cancers

Nitin S. Baliga, Ph.D., Professor, Senior Vice President & Director, Research and Education, Institute for Systems Biology


GENOME EDITING USING CRISPR/CAS9 TECHNOLOGY

Targeted Isolation and Cloning of 100-kb Microbial Genomic Sequences by Cas9-Assisted Targeting of Chromosome Segments

Ting Zhu, Ph.D., Investigator & Associate Professor, School of Life Sciences, Tsinghua University

CRISPR/Cas9-Mediated Multiplex Genome Editing for Efficient CHO Cell Engineering

Byung-Kwan Cho, Ph.D., Associate Professor, Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST)

In vivo Genome Engineering via CRISPR/Cas Systems

Ana Moreno, Research Scientist, Bioengineering, University of California, San Diego

A High-Throughput Method for Parsing Complex DNA Libraries and Engineering Yeast

Robert St. Onge, Ph.D., Senior Research Scientist, Stanford Genome Technology Center, Stanford University


CASE STUDIES: CELL LINE ENGINEERING

Engineering Mammalian Cells for Desired Bioprocess and Protein Quality Attributes

Nathan E. Lewis, Ph.D., Assistant Professor, Pediatrics, University of California, San Diego

Engineering Recombinant mRNAs for Increased Protein Expression, Better Secretion, and Improved Cell Physiology

Vincent P. Mauro, Ph.D., CSO & Senior Vice President, Promosome, LLC

The IR/MAR Gene Amplification Technology and Recombinant Production

Noriaki Shimizu, Ph.D., Professor, Graduate School of Biosphere Science, Hiroshima University

Improvements to the Baculovirus-Based Insect Cell Expression System to Enhance Protein Yield and Quality

Dominic Esposito, Ph.D., Director, Protein Expression Laboratory, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc.




For questions about the meeting, please contact:

Mary Ann Brown
Executive Director, Conferences
Cambridge Healthtech Institute
Phone: 781-972-5497
Email: mabrown@healthtech.com

For partnering & sponsorship information, please contact:

Companies A-K
Jason Gerardi
Manager, Business Development
Cambridge Healthtech Institute
Phone: 781-972-5452
Fax: 781-972-5470
Email: jgerardi@healthtech.com

Companies L-Z
Carol Dinerstein
Director, Business Development
Cambridge Healthtech Institute
Phone: 781-972-5471
Fax: 781-972-5470
Email: dinerstein@healthtech.com