January 18-22, 2016 | Town and Country Resort Hotel | SAN DIEGO, CA 
January 18-22, 2016 | Town and Country Resort Hotel | SAN DIEGO, CA 

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Cambridge Healthtech Institute’s 12th Annual
Recombinant Protein Therapeutics
Fusion Proteins and Beyond
January 18-19, 2016


Cambridge Healthtech Institute’s Recombinant Protein Therapeutics conference explores the customizable functionality of fusion protein therapeutics, which possess advantages over antibody-based therapies by combining modular building blocks that can reach targets not accessible to antibodies. Additional advantages include lower patient dosing, reduced production costs and improved product homogeneity. This meeting explores the varying constructs and “designs” of fusion protein molecules, and discloses how these proteins are being engineered to form more efficacious therapeutics that offer specificity with enhanced stability and longer half-life. Experts present case studies from R&D through clinical data, and share the results they’ve achieved.

Preliminary Agenda 


CROSSING THE BBB

Re-Engineering Lysosomal Enzyme Therapeutics for the Brain as IgG Fusion Proteins that Penetrate the Blood-Brain Barrier

Ruben Boado, Ph.D., Vice President, R&D, ArmaGen, Inc.


TARGETING CANCER

Targeting MUC16-Positive Malignancies with the Novel TRAIL-Based Cancer Therapeutic Meso64-TR3

Dirk Spitzer, Ph.D., Instructor, Surgery, Washington University School of Medicine

Potential Role of LEC/Antibody Fusion Protein in the Immunotherapy of Cancer

Alan L. Epstein, M.D., Ph.D., Professor, Pathology, University of Southern California Keck School of Medicine

Engaging Innate and Adaptive Immunity Using Cancer-Reactive Immunocytokines

Paul M. Sondel, M.D., Ph.D., Professor, Pediatrics, Hematology & Oncology, University of Wisconsin, Madison


OVERCOMING DISEASE

Development of Luspatercept: A Receptor Fusion Protein Engineered to Treat Diseases of Ineffective Erythropoiesis

Ravindra Kumar, Ph.D., CSO, Acceleron Pharma, Inc.

Development of Physiocrine-Based Therapeutics

Andrew Cubitt, Ph.D., Vice President, Intellectual Property, aTyr Pharma, Inc.


INNOVATIVE ENGINEERING

Affibody-Based C5 Inhibitors for Targeting the Terminal Complement Pathway

Patrik Strömberg, Ph.D., Head, Biomedical Science and Portfolio Innovation, Swedish Orphan Biovitrum AB (SOBI)

Next-Generation FVIII Fusion Protein Incorporating Both XTEN Insertions and von Willebrand Factor

Robert Peters, Ph.D., Vice President, Hematology Research, Biogen


IMPROVING PROPERTIES AND STRATEGIES

Fc Engineering to Increase Half-Life and Reduce Effector Functions

Céline Monnet, Ph.D., Senior Scientist, Molecular Design Unit, Innovation Department, LFB Biotechnologies

Unique Profile of the Weekly Insulin HM12470: Very Slow Onset of Action, Rapid Off-Rate Similar to Insulin and Absence of Insulin Receptor Downregulation

Juergen Eckel, Ph.D., Professor and Research Head, Paul-Langerhans-Group, German Diabetes Center

Targeting Therapeutic with an Antibody Specific to Damaged Arthritic Cartilage

Ahuva Nissim, Ph.D., Reader, Antibody and Therapeutic Engineering, Biochemical Pharmacology, Queen Mary University

Manufacturing of Recombinant Protein Therapeutics under Cost Constraints

Stefan Schmidt, Ph.D., MBA, Vice President, Process Science and Production, Rentschler Biotechnology

Novozymes CroppedPresentation to be Announced






For questions about the meeting, please contact: 

For partnering & sponsorship information, please contact: 

Mary Ruberry
Senior Conference Director
Cambridge Healthtech Institute
Phone: 781-972-5421
Email: mruberry@healthtech.com 

Companies A-K
Jason Gerardi
Manager, Business Development
Cambridge Healthtech Institute
Phone: 781-972-5452
Fax: 781-972-5470
Email: jgerardi@healthtech.com 

Companies L-Z
Carol Dinerstein
Director, Business Development
Cambridge Healthtech Institute
Phone: 781-972-5471
Fax: 781-972-5470
Email: dinerstein@healthtech.com