Cambridge Healthtech Institute’s 2nd Annual

Intelligent Antibody Discovery: Part One

Next-Generation Technologies for Repertoire Sequencing and Single Cell Interrogation

January 16-17, 2023

 

Peptalk’s two-part Intelligent Antibody Discovery conference explores the technologies, informatics, and strategies driving a move to improve the quality, precision, and developability of biotherapeutic selections – all at very high throughput. Part One examines new capabilities of NGS and repertoire sequencing tools, strategies for developing and implementing high-throughput functional assays, and the challenges of using outputs from these studies in next-generation computational models based on AI and machine learning. Part Two then builds on this foundation to consider current and near-term applications of machine learning in antibody discovery – and offers insights into implementing these tools in a discovery operation and the wet lab validation of predicted sequences and structures. The program also examines the status of efforts to apply these tools to the de novo design of antibodies and other therapeutic proteins.  

 

Coverage will include, but is not limited to:

 

Advancing the Capabilities of Repertoire Sequencing

  • Deep mutational scanning
  • Microarray and bead-based technologies to correlate biophysical and sequence information
  • Mining and characterizing natural sequence diversity

 

Improving the Resolution and Range of Single Cell Analysis

  • Best practices for assay design and development
  • Novel single cell and bioinformatic workflows for improved clone selections
  • Single cell multiomics

 

High-Throughput Functional Assays

  • Approaches for translating assays from reporter lines to primary cells
  • Automation and/or semi-automation to improve throughput
  • Leveraging NGS in combination with binding and functional assays

 

Emerging Platforms and Capabilities

  • Emerging single cell technology platforms with novel capabilities
  • Linking studies of antigen specificity with B cell receptor sequencing in single cells
  • The challenges and benefits of homegrown solutions

 

Challenges and Solutions

  • Applications of B cell screening with novel immunizations
  • Targeting challenges (TCR mimetic proteins, intracellular targets, membrane proteins)
  • Technologies and workflows for progressing from sample to validated antibodies

 

Integrating NGS and Single Cell Technologies with Machine Learning

  • Adapting data outputs from NGS/single cell platforms to computational and ML models
  • Approaches to integrating functional screening, single cell, and ML
  • Understanding the data requirements of ML/AI: structure, volume, quality considerations

 

The deadline for priority consideration is July 1, 2022.

 

All proposals are subject to review by session chairpersons and/or the Scientific Advisory Committee to ensure the overall quality of the conference program. Additionally, as per Cambridge Healthtech Institute’s policy, a select number of vendors and consultants who provide products and services will be offered opportunities for podium presentation slots based on a variety of Corporate Sponsorships.

 

Opportunities for Participation:

 

 

For more details on the conference, please contact:

Kent Simmons

Senior Conference Director

Cambridge Healthtech Institute

Phone: +1 207-329-2964

Email: ksimmons@healthtech.com

 

For sponsorship information, please contact:

 

Companies A-K

Jason Gerardi

Sr. Manager, Business Development

Cambridge Healthtech Institute

Phone: +1 781-972-5452

Email: jgerardi@healthtech.com

 

Companies L-Z

Ashley Parsons

Manager, Business Development

Cambridge Healthtech Institute

Phone: +1 781-972-1340

Email: ashleyparsons@healthtech.com