Cambridge Healthtech Institute’s Inaugural

Advancing Multispecific Engineering to the Clinic

January 21-22, 2026

Cambridge Healthtech Institute’s Inaugural Advancing Multispecific Engineering to the Clinic conference connects the protein-engineering bench to real-world clinical performance. We open with an AI-driven design session that blends in silico modeling, generative algorithms, data-driven design, and machine-learning tools for precision selectivity, affinity tuning, optimization, and developability. Two companion sessions then dissect multispecific candidates already in the clinic—spanning T cell engagers and other first-in-class molecules—to show how co-stimulation strategy, toxicity management, and adaptive trial design loop critical insights back to engineering teams. Bring your latest data to a podium, poster, or sponsor slot and help transform your computational and engineering vision into patient-ready multispecifics.

Coverage will include, but is not limited to:

AI and Computational Multispecific Design

In silico design and validation for novel scaffolds, VHHs, and synthetic constructs
AI/ML for

Tuning selectivity and affinity
Optimization and developability
De novo design

T Cell Engagers

Raising capital in the early phases of research
TCEs in blood cancers, solid tumors, and autoimmunity
Immunogenicity, off-target toxicity, and cytokine release
Mitigating toxicity
Co-stimulation
TCR-based T cell engagers
FC engineering

Promising Candidates

Effective clinical trial design
Candidates showing promise and why
Success stories
New admin guidance about minimizing animal studies and incorporating new methodologies
Clinical learnings that impact discovery

The deadline for priority consideration is June 27, 2025.

All proposals are subject to review by session chairpersons and/or the Scientific Advisory Committee to ensure the overall quality of the conference program. Additionally, as per Cambridge Healthtech Institute’s policy, a select number of vendors and consultants who provide products and services will be offered opportunities for podium presentation slots based on a variety of Corporate Sponsorships.

Opportunities for Participation: