Cambridge Healthtech Institute’s 26th Annual

Recombinant Protein Production – Part 2

January 15-16, 2025


Welcome to Cambridge Healthtech Institute's 26th Annual Recombinant Protein Production – Part 2 track, where we tackle the latest challenges and solutions in producing cutting-edge therapeutics. Explore how to optimize the stability and expression of bi- and multi-specific antibodies, ADCs, virus-like particles, cytokines, and many other therapeutic proteins. Discover emerging and next-gen approaches related to construct design, machine learning, cell-free systems, overcoming misfolding, and library design. Gain insights into workflow and data optimization for improved production efficiency. Join us at the forefront of therapeutic protein expression innovation.


Coverage will include, but is not limited to:


Bi- and Multi-specific Antibodies and ADCs

  • Optimizing the stability and expression of
    • Bispecific and multispecific antibodies
      • FC fusion proteins
    • Antibody-drug conjugates (ADCs)
  • Controlled and consistent drug antibody ratio (DAR) for antibody drug conjugates (ADCs)
  • Retaining specificity and affinity of multispecific antibodies through production
  • Matching your host to your protein of choice
    • CHO
    • Yeast
    • Baculovirus-Insect
    • Bacterial
    • Mammalian
  • Applications of high-throughput cell free systems: microfluidic devices and lysate optimization


Other Therapeutic Protein Classes

  • improving the stability and expression of
    • Virus like particles (VLPs)
    • Vaccines
    • Viral Vectors
    • Cytokines
    • Hormones
    • Enzymes
  • Re-engineering existing systems for better performance
  • Matching your host to your protein of choice
  • High cell-throughput cell free systems for production: microfluidic devices and lysate optimization

Emerging and Next-Gen Techniques and Technologies for Improving Production

  • Protein bioconjugation for expanded functionality
  • Machine learning (ML) and construct design
  • Alpha fold applications
  • Structural biology techniques for optimizing function and targeting (x ray crystallography, NMR)
  • Computational tools for measuring, preventing, and predicting protein aggregation
  • Library design and analysis of large data sets for host cell, vector, and construct selection
  • Time and cost-conscious production
  • Optimizing media and culture conditions
  • Overcoming misfolding

Workflow and Data Optimization for Improved Protein Production

  • Collaboration for improved research outcomes
  • Streamlining data collection
  • Managing multiple projects
  • Integrating automation into the lab
  • Personnel and resource management


The deadline for priority consideration is June 28, 2024.


All proposals are subject to review by session chairpersons and/or the Scientific Advisory Committee to ensure the overall quality of the conference program. Additionally, as per Cambridge Healthtech Institute’s policy, a select number of vendors and consultants who provide products and services will be offered opportunities for podium presentation slots based on a variety of Corporate Sponsorships.


Opportunities for Participation:


For more details on the conference, please contact:

Nikki Cerniuk

Conference Producer

Cambridge Healthtech Institute

Phone: (+1) 781-972-1350



For sponsorship information, please contact:


Companies A-K

Jason Gerardi

Sr. Manager, Business Development

Cambridge Healthtech Institute

Phone: +1 781-972-5452



Companies L-Z

Ashley Parsons

Manager, Business Development

Cambridge Healthtech Institute

Phone: +1 781-972-1340