Cambridge Healthtech Institute’s 27th Annual

Recombinant Protein Production – Part 2

January 21-22, 2026

 

Cambridge Healthtech Institute’s 27th Annual Recombinant Protein Production – Part 2: Therapeutics is all about making more—and better—recombinant protein therapeutics. Whether you’re producing bispecifics, Fc fusions, scFvs, enzymes, peptides, AAVs, VLPs, or other complex payloads, the program delivers hands-on strategies for squeezing functional protein from CHO, HEK, insect, bacterial, and cell-free systems. Here we discuss construct-design tactics—codon-optimized vectors, tunable promoters, and hybrid workflows—that increase titers without sacrificing quality. An emerging-tech session highlights AI/ML-guided modeling for VHH and Fc fusion proteins, automation that speeds assembly, and cryo-EM or advanced MS for early developability checks. Talks on tricky post-translational modifications (glycosylation, phosphorylation, methylation, lipidation) pair with case studies on solving misfolding and maximizing multimer assembly. Finally, workflow and economics panels tackle sustainability, smart in-house vs. outsourced production, and running multiple high-priority projects in parallel. Bring your best data—or secure a sponsor slot—and help push therapeutic protein production to new heights.

 

Coverage will include, but is not limited to:

 

Production of Bispecifics and Therapeutics Beyond

  • Comparative analysis of different expression systems
  • Cell free systems in the context of therapeutic proteins
  • Tailoring promoters to control protein production timing and level
  • Therapeutic proteins with difficult post-translational modifications
    • Glycosylation, Phosphorylation, Methylation, lipidation
  • Therapeutic protein production
    • Bispecific, multispecific, multifunctional proteins
    • IGEs
    • FC fusion proteins
    • SCFVs
    • Peptides
    • AAVs
    • VLPs
    • Toxic Proteins
    • Reagent production
    • Enzymes
  • Therapeutic proteins with difficult post-translational modifications
    • Glycosylation, Phosphorylation, Methylation, lipidation

Emerging Technologies for Developability and Production

  • Improving yield
  • In silico, AI, ML, construct design, modeling, and prediction
    • Modeling of VHHs, Bispecifics, FC Engineering
  • Automation
  • Optimizing assembly
  • Tools for structural validation of novel therapeutic classes
    • Cryo-EM
    • MS

Workflows and Process Economics

  • Sustainability: How do we make proteins less expensive to improve access
  • When to in-source vs outsource production
  • How to manage multiple top priority projects

 

The deadline for priority consideration is June 27, 2025.

 

All proposals are subject to review by session chairpersons and/or the Scientific Advisory Committee to ensure the overall quality of the conference program. Additionally, as per Cambridge Healthtech Institute’s policy, a select number of vendors and consultants who provide products and services will be offered opportunities for podium presentation slots based on a variety of Corporate Sponsorships.

 

Opportunities for Participation:

 


For more details on the conference, please contact:

Nikki Cerniuk

Conference Producer

Cambridge Healthtech Institute

Phone: 781-972-5400

Email: ncerniuk@healthtech.com

 

For sponsorship information, please contact:

 

Companies A-K

Jason Gerardi

Sr. Manager, Business Development

Cambridge Healthtech Institute

Phone: 781-972-5452

Email: jgerardi@healthtech.com

 

Companies L-Z

Ashley Parsons

Manager, Business Development

Cambridge Healthtech Institute

Phone: 781-972-1340

Email: ashleyparsons@healthtech.com