Cambridge Healthtech Institute’s 27th Annual
Recombinant Protein Production – Part 2
January 21-22, 2026
Cambridge Healthtech Institute’s 27th Annual Recombinant Protein Production – Part 2: Therapeutics is all about making more—and better—recombinant protein therapeutics. Whether you’re producing bispecifics, Fc fusions, scFvs, enzymes, peptides, AAVs, VLPs, or other complex payloads, the program delivers hands-on strategies for squeezing functional protein from CHO, HEK, insect, bacterial, and cell-free systems. Here we discuss construct-design tactics—codon-optimized vectors, tunable promoters, and hybrid workflows—that increase titers without sacrificing quality. An emerging-tech session highlights AI/ML-guided modeling for VHH and Fc fusion proteins, automation that speeds assembly, and cryo-EM or advanced MS for early developability checks. Talks on tricky post-translational modifications (glycosylation, phosphorylation, methylation, lipidation) pair with case studies on solving misfolding and maximizing multimer assembly. Finally, workflow and economics panels tackle sustainability, smart in-house vs. outsourced production, and running multiple high-priority projects in parallel. Bring your best data—or secure a sponsor slot—and help push therapeutic protein production to new heights.
Coverage will include, but is not limited to:
Production of Bispecifics and Therapeutics Beyond
- Comparative analysis of different expression systems
- Cell free systems in the context of therapeutic proteins
- Tailoring promoters to control protein production timing and level
- Therapeutic proteins with difficult post-translational modifications
- Glycosylation, Phosphorylation, Methylation, lipidation
- Therapeutic protein production
- Bispecific, multispecific, multifunctional proteins
- IGEs
- FC fusion proteins
- SCFVs
- Peptides
- AAVs
- VLPs
- Toxic Proteins
- Reagent production
- Enzymes
- Therapeutic proteins with difficult post-translational modifications
- Glycosylation, Phosphorylation, Methylation, lipidation
Emerging Technologies for Developability and Production
- Improving yield
- In silico, AI, ML, construct design, modeling, and prediction
- Modeling of VHHs, Bispecifics, FC Engineering
- Automation
- Optimizing assembly
- Tools for structural validation of novel therapeutic classes
Workflows and Process Economics
- Sustainability: How do we make proteins less expensive to improve access
- When to in-source vs outsource production
- How to manage multiple top priority projects
The deadline for priority consideration is June 27, 2025.
All proposals are subject to review by session chairpersons and/or the Scientific Advisory Committee to ensure the overall quality of the conference program. Additionally, as per Cambridge Healthtech Institute’s policy, a select number of vendors and consultants who provide products and services will be offered opportunities for podium presentation slots based on a variety of Corporate Sponsorships.
Opportunities for Participation: