Cambridge Healthtech Institute’s

Vectors for Targeted Delivery

January 13, 2025

Join us for Cambridge Healthtech Institute's Vectors for Targeted Delivery symposium where we discuss ways to engineer safe and effective vectors, optimize capsids, and perfect payloads. Here we discuss ways to optimize a variety of viral and non-viral vectors through increasing titers, improving tissue specificity, mitigating immunogenicity and cytotoxicity, improving transgene efficiency, implementing machine learning, scaling-up manufacturing, navigating regulatory requirements, and more! Discover groundbreaking advancements with tools and techniques that are furthering mRNA delivery, cell therapy, and gene therapy through the transformative capabilities of vectors.

Coverage will include, but is not limited to:

Engineering Safe and Effective Vectors

Effective engineering of viral vectors:

Adeno-associated vectors (AAVs)
Adenoviral vectors (Avs)
Lentiviral vectors (LVs)
Retroviral Vectors

Effective engineering of non-viral vectors

Lipid nanoparticles (LNPs)
Polymer-based vectors
Virus-like particles (VLPs)
Liposomes
Exosomes
Gold nanoparticles

Applications to mRNA, cell therapy, and gene therapy
Increasing infectious titers and improving transgene efficiency
Managing systematic toxicity and insertional mutagenesis
Improving tissue specificity
AI-powered discovery and design of vectors
Capsid optimization:

Improving capsid permeability
Customizing capsid fill-rate
Bioconjugation of capsids
Managing immunogenicity

From Perfecting the Payload to Targeted Delivery

Optimizing encapsulation efficacy and capacity
Preserving cargo activity
Cassette design for ideal safety and expression profiles
Controllable transgene expression
Strategies for cellular uptake and endosomal escape
Novel vectors for improved delivery

Successful Scale-Up

Effective vector manufacturing and scale-up
Navigating regulatory requirements
Improving yield
Quality control

The deadline for priority consideration is June 28, 2024.

All proposals are subject to review by session chairpersons and/or the Scientific Advisory Committee to ensure the overall quality of the conference program. Additionally, as per Cambridge Healthtech Institute’s policy, a select number of vendors and consultants who provide products and services will be offered opportunities for podium presentation slots based on a variety of Corporate Sponsorships.

Opportunities for Participation: