2022 PepTalk Keynote Presentations:

Antibody Discovery & Engineering

Merging MOA, Structural Information & Single Cell Screening to Identify Potent mABs as Potential Therapeutic Candidates
John WilliamsJohn Williams, PhD, Professor of Molecular Medicine and Co-Director, Drug Discovery and Structural Biology Core, Beckman Research Institute at City of Hope

CDR Swapping and Multivalency Protein Engineering Approaches for Generating Broadly Neutralizing Nanobodies against SARS-CoV-2
Peter M. TessierPeter M. Tessier, PhD, Albert M. Mattocks Professor, Pharmaceutical Sciences & Chemical Engineering, University of Michigan

Protein & Antibody Therapeutics

Developability of Bispecific Antibodies
Paul ParrenPaul Parren, PhD, Executive Vice President, Lava Therapeutics; Professor, Leiden University Medical Center

Trispecific Antibodies – Taking the Concept of Multi-Targeting One Step Further
Ercole RaoErcole Rao, PhD, Group Leader Biologics Research, Engineered Protein Therapeutics, Sanofi Germany GmbH

Chimeric Antigen Receptor-Modified Immune Effector Cell Therapies: Learning from the Present; Charting a Path to the Future
Renier J. BrentjensRenier J. Brentjens, PhD, Director, Cellular Therapeutics, Human Oncology & Pathogenesis Program, Memorial Sloan Kettering Cancer Center

Characterization & Aggregation in Biopharmaceuticals

A Systematic Approach to Evaluating Closed System Transfer Devices (CSTDs) During Drug Product Process Development
Sanket PatkeSanket Patke, PhD, Associate Director, Sanofi

Novel Degradation Mechanisms of Polysorbate: Complex Reaction Pathways of a Complex Surfactant
Christian SchoeneichChristian Schoeneich, PhD, Takeru Higuchi Distinguished Professor & Chair, Pharmaceutical Chemistry, University of Kansas Lawrence

Requirements for Particulates in the European Pharmacopeia
Hanns-Christian MahlerHanns-Christian Mahler, PhD, Board Member, Bionter AG

Cell & Gene Therapy

Non-Radioactive Assays for Cell Therapies
Chaudhary_PreetPreet M. Chaudhary, MD, PhD, Professor & Chief Hematology & Director, Blood & Marrow Transplant, University of Southern California

Nucleic Acids as Household Medicine: Living in the World of RNA Therapeutics
Manoharan_MuthiahMano Manoharan, PhD, Distinguished Scientist & Senior Vice President, Innovation Chemistry, Alnylam Pharmaceuticals

Biotherapeutic Expression & Production

Cell Engineering Efficiency and Quality
du_zhimeiZhimei Du, PhD, Director, Biologics & Cell Therapeutics Process Development, Merck and Co., Inc.

Lessons Learned from Expression Liabilities in a Four-Chain Bispecific
Hubert_ReneRene Hubert, PhD, Director, Biologics Optimization, Amgen Inc.

Protein Production & HTP

Advances in High-Throughput Protein Purification at Different Scales
Kawooya_JohnJohn K. Kawooya, PhD, Director, Biologics Optimization and Therapeutic Discovery, Amgen Inc.

High Performance Countercurrent Membrane Purification (HPCMP) for Continuous Downstream Processing
Zydney_AndrewAndrew Zydney, PhD, Bayard D. Kunkle Chair & Professor, Chemical Engineering, Pennsylvania State University